What to Do About Your COMT Genes | Chris Masterjohn Lite #42

You're a gift! Serously! The service you are doing to humanity....! Regarding Glycine...is it ok to take Magnesium Glycinate instead? I assume it should also increase glycine

Could you say is Betaine Hcl (as stomach acid supplement) is a methyl donor as Betaine (TMG)?

“ Please What Info On Aminos “ And Taurine “ For How Many Benifits “!

Chris , firstly thanks for a very informative video .

What's your opinion , in terms of bioavailability , of vit. b supplements in comparison with natural b vitamin sources? Do artificial supplements have a place in world that heavily relies on convenience these days?

Please help how do you speed up the COMT enzyme I’m stressed all the time and can’t relax

Good video. But it irks me when people talk about COMT causing anxiety as a matter of fact. Well, it sort of does but the mechanism is more indirect: Higher levels of estrogen accumulate copper, which causes the mood and concentration symptoms. Chelate the copper out with alpha lipoic acid (and something like curcumin and/or carnosine to aid in elimination because ALA has a short half-life), and things should stabilize. Also, resveratrole is efficient in removing estrogen from the blood stream.


Oh, and estrogen raises prostaglandin E2 which can cause gastrointestinal issues, especially diarrhea.


We do need significantly more magnesium than the average person. Partially because the stress hormone cortisol removes magnesium and potassium from the body. But overall I consider my +/+ to be more of an asset than a hindrance.

Honestly I was so grateful to learn I was AA. It provided a cause for so much of the behavior I exhibited over the years that was inexplicable to me and extremely frustrating. It's truly a double edged sword. I have an excellent memory, divergent thinking, am great at hyper-focusing on subjects I am passionate about, etc., but I also have ADHD and severe anxiety. Not only that, but of course under pressure I collapse. I always felt smart yet had so much trouble demonstrating that in many real life situations, and I'm so happy to learn this is a gift as much as it is a curse. Hopefully following a methylation protocol will help me with some of the more adverse effects of having this gene variant.

Great info! Do you have any videoes on glycine buffers?

Excellent explanation as usual!! I have the slowed COMT variant, but on doing a Methylation Profile blood test, i was found to have ultra high levels of SAH, which can slow COMT further. Lowering the SAH has helped a lot & making sure to get magnesium from various sources as magnesium drives COMT too.

He kept looking like Jordan Peterson on me. I had to blink my eyes, slow COMT.

Good information, thanks Dr. Masterjohn.

I have low COMT activity (AA) and yeah, negative thoughts and stress really drains me, which makes it impossible to keep any job. On the counterpart I also have ADD/ADHD, which paradoxically is quite common with low COMT activity, because of too much dopamine in prefrontal cortex. Low COMT can also increase norepinephrine which in turn increases restlessness. High norepinephrine also leads to poor blood flow and digestion, so it is hard for the brain and body to get enough nutrients. I'm a normal methylator, and glycine supplements really makes me ill and my stomach upset (even with food). DIM supplements may be an alternative but it makes me ill as well. SAMe too (and not suitable for normal methylators). Is there a way to increase COMT activity without SAMe? Or to increase breakdown of estrogen?

I need to Slow down COMT so besides quercetin and fisetin what else is More effective?

Hi Chris, thanks for your insights. Please help me understand the role of glycine for my very slow COMT gene. I am taking a good quality magnesium glycinate and I am not sure if it causing me the issues. DO I understand correctly that it slows down the COMT gene capabilities even more, so that people with fast COMT should use it to keep some of their dopamine? Thanks in advance for your help!

Hi Chris, thanks for your insights. Please help me understand the role of glycine for my very slow COMT gene. I am taking a good quality magnesium glycinate and I am not sure if it causing me the issues. DO I understand correctly that it slows down the COMT gene capabilities even more, so that people with fast COMT should use it to keep some of their dopamine? Thanks in advance for your help!

Three snips of COMT ++, ++, - -. Blessing and a curse. Hyper focused on subjects or projects of interest. ADD for everything else. Excessive thirst for information. Tendency to hyper focus on single subjects for 3-6 months a time. Hard to find a healthy balance and unlatch from interest in focus.

Does the entire population have rs4680

Hi, just found your brilliant videos. I have lack of MTHFR, HMNT, DAO and a double mutation on COMT making it slow. I’m trying to figure out what supplements I need to help with all of them. Is there a list for each that I can cross reference? I can’t have quercitin for my histamine issues because I read it slows down my comt even more. Thank you

How do i know if i need glycine?I have slow COMTS.

So where the heck am I supposed to find someone to personally work with me on all of this?

I am met/met as I always suspected from my optimism and tendency to get addicted to stimulants. Unfortunately, my levels of anxiety have always been through the roof. I ahve an enormous amount of difficulty emotionally relaxing.

I have breast cancer that is 100% estrogen driven. I also just found out I have the "slow COMT enzyme" I know there is a connection but don't understand what I should do. Dr's don't get this. Do I need more magnesium, Vit C, B complex and DIM? Please help.

Hello, I downloaded my row data from AncestryDNA and didn't find rs4680 sharp I found nearly 20 genes start with rs4680 followed by three other digits like rs4680353.

I read AG’s should not take methylated vitamins and do you mean to supplement with glycine?

I have a warrior mutation, and I am not sure if maybe trying to increase my dopamine would be a good idea or not? Because I definitely feel a lack of motivation and drive in life, I feel quite apathetic. I have the MTHFR compound heterozygous plus the transporter gene variation (all bad). So I am trying to optimize that. Basically my mood, energy and drive are all low, I believe my baseline is rather good (good diet, exercise, sleep).

I’m met/met. What supplements and nutrients do I need to make sure I have ?

Awesome, thank you

Where do you get this test done? I want the exavt test he did

I’m homozygous for MTHFR a1298C and COMT. I’m so clueless as to what to do next.

Hey Chris,

What would you suggest for someone with MTHFR C677T T/T and COMT Val/Val? How do I support the building of neurotransmitters without speeding up the breakdown by adding too many methyl groups?

Also, I seem to have character traits of a Met/Met. Is that just a variation caused by certain factors? Is it epigenetic expression (maybe caused by methylation impairment)?

Haha. This video describes me so good. I am very mentally rigid most of the time, but sometimes its impossible for me to concentrate. Taking glycine makes me anxious. This is so complex 😮‍💨

HI Chris. It's Chris. I am a COMT ++. What do I take to counteract the low COMT ++ activity? I have horrible imbalances in mood and low energy. I, burn out easily and can't adapt to stress and everything bothers me. Every kind for of stressor just echos and echos. I also have CYP1B1 and CYP2C9 polymorphisms on phase 1 of liver detoxification.

Anyone here have that uncontrollable urge to stretch your calf's, feet, toes, shoulders, neck, mouth, face pop neck pop shoulder, cant sit still in a restaurant like just feel antsy n urge to move/stretch body????????

thx v clear concise

I am +/- for this , interesting... thank you..... mentally rigid and difficult to let go of things... LOL this can be me hahahah.... so good 2 have the answers for this.

I am Comt ++ and I am feeling this so much! I get stuck on a loop! Please help me. I cannot decifer my stratagene.

Coming from someone who is ASD and has noticed a significant uptick in my obsessions / special interests, I suspected this was happening to me right now... But it's still a slap in the face. Oh geez.

None of this works for me because I have the CBS mutation.

Im missing the links he mentioned in the video comment about glycine buffer.

Thank you! It's been difficult to find good explanations about COMT and you broke it open for me. I am +/- but thought I might not have been - yes I agree it is misleading to highlight it this way. I have other SNPs that probably explain why I have difficulty downregulating neurotransmitters.

I don't see the link to order the strategene report.

What happens if u have both mthfr and comt?

I did an expensive genetic test with 10X health which helped in some ways, however they didn’t tell me specifically if I was a +/+ or -/- etc…

How do I find out which specific COMT gene mutation I have?

I definitely get stuck on things and cannot transition well.
I Definitely have social rigidity…😓

Frustrating to get so close to answers and then don’t quite get conclusive answers.😓

Chris...amazing narrative! Made it so easy to understand! I have recently come to find out that I am homo on rs 4633, 4646312, 4680 and hetero on rs933271. Everything you say is true...great student when I want to focus...can focus on playing music for hours at a stretch...VERY mentally rigid and obsessive. On my way to health with HYDROXY B12 (methyl made me MUCH worse). Keep up the gr eat work!

Can you do a video on MAO-A?

How do you test for this COMT?

If I have my raw gene data where or what company can I upload my genes through to get this detailed of a report?