Sustainable and people-centred mobility solutions designed today must be prepared for decades to come. Evaluating social and environmental impacts through simulation is crucial but challenging due to various social and technological uncertainties. We developed a transdisciplinary approach linking scenarios, personas, and synthetic populations to simulate 2030 scenarios of Paris and Cairo. The method is applied to intermodal AV services and its results highlight anticipated impacts on emissions, energy demand, and individual costs across scenarios and user groups.